Nifedipine controlled-release tablets can be taken at the same time with Irbesartan Hydrochlorothiazide tablets, there is no contraindication to the two. Nifedipine controlled-release tablets are calcium channel blockers, which can be used to treat hypertension, coronary heart disease and other diseases; Irbesartan Hydrochlorothiazide Tablets are anti-hypertensive drugs, which can be used to treat essential hypertension. For refractory hypertension, if the effect of controlling blood pressure with nifedipine controlled-release tablets alone is not satisfactory, Irbesartan Hydrochlorothiazide Tablets can be taken jointly, so the two can be taken at the same time. It should be noted that the adverse reactions of nifedipine controlled-release tablets include edema, headache, anxiety, sleep abnormality, etc. It is forbidden for those who are allergic to nifedipine or any ingredient in this product. Irbesartan hydrochlorothiazide tablets adverse reactions include dizziness, nausea, vomiting and abnormal urination, etc. It is prohibited for those who are allergic to this product. Nifedipine controlled-release tablets can be taken at the same time with Irbesartan Hydrochlorothiazide Tablets, but need to be taken under the guidance of a doctor, not unauthorized use of medication, to avoid adverse reactions and health hazards.