Hand swelling after waking up in the morning can be caused by the following reasons: first, cervical spondylosis, when cervical spondylosis compresses the nerves, there can be disorders of the vegetative nerves, resulting in poor venous return, the symptoms of swollen hands in the morning, which can be accompanied by numbness of the hands, then early physical examination, early examination of cervical spine X-rays, CT to diagnose and early treatment. Second, rheumatoid, when rheumatoid involvement of the fingers, there can be morning swelling of the fingers, which can be accompanied by pain and finger deformity, limited movement, then early blood tests and X-rays of the hand to diagnose and early treatment. Third, ankylosing spondylitis, severe ankylosing spondylitis can lead to morning swelling of the hand, finger pain, can be accompanied by pain in the sacroiliac joint, then we should check the sacroiliac joint, lumbar spine x-ray, blood tests for early diagnosis and early treatment.