The main side effect of Gentian and Liver Pill is the possibility of kidney damage, which is thought to be caused by the aristolochic acid contained in Guanmutong in the medicine [1]. Now Guanmutong has been replaced by Moutong, while Baimutong does not contain aristolochic acid and is relatively safer, but the application should be treated with care and chosen according to the type of evidence, such as indeed damp-heat in the liver and gallbladder can only be applied, otherwise even the therapeutic effect will become a side effect. Patients with a cold body should also not use more. Cold body nature is an excess of yin inside the body, resulting in the imbalance of yin and yang. Specific manifestations: the internal organs sag, the digestion and absorption of nutrients are weakened, so that the body absorbs less heat, and the body is cold. Do not often drink water will not feel thirsty, often feel mentally weak and easily fatigued, pale face, pale lips, fear of cold, fear of blowing wind, cold hands and feet, like to drink hot drinks, eat hot food, often diarrhea, often urinate and light color, etc. When taking Gentian Liver Pill, if you take this medicine, after three days, you find that the symptoms are still not relieved, you should immediately stop the medicine and need to go to a regular liver hospital for examination. For some people who have high blood pressure, heart disease, liver disease, kidney disease, fine and soft stools, old and weak patients, infants and children, pregnant women should be used with caution.