Forefoot whitening is mostly considered to be caused by tinea pedis, anemia and other diseases, which need to be clearly diagnosed and then choose the appropriate medication, such as antifungal drugs, iron, etc., for treatment. 1. Tinea pedis: tinea pedis can cause foot skin keratinization, thickening, desquamation, resulting in white feet, can be used externally to exfoliate stronger preparations, such as compound benzoic acid ointment, combined with antifungal drugs, such as naftifine ketoconazole, etc.; such as external drugs can not be relieved, can be taken orally to treat the antifungal drugs, such as itraconazole, terbinafine and so on. 2. Anemia: patients with anemia may have pale skin at the end of the limbs, and need to clarify the nature of the anemia and target treatment. If it belongs to iron deficiency anemia, oral iron treatment, such as ferrous fumarate tablets, ferrous sulfate tablets, etc.; if it belongs to megaloblastic anemia, supplemental folic acid, vitamin B12 and other treatments. It is recommended that patients go to the dermatology department of regular hospitals in a timely manner, follow the doctor’s instructions to clarify the diagnosis and timely treatment to avoid delaying the condition. When using medication, strictly comply with the doctor’s prescription medication, not blindly self-medication.