Prostate enlargement and calcification is often the result of ultrasound, whether it is serious or not needs to be discussed in different situations, may be due to prostatitis, may also be due to prostate hyperplasia, these two cases are not serious, but there may be due to prostate cancer, this situation is more serious. 1. Prostatitis: prostatitis can lead to prostate enlargement and calcification when the patient undergoes ultrasound examination, this situation is not serious, only need to be treated for prostatitis, you can use levofloxacin, azithromycin, doxycycline and other medications for treatment. 2. Prostatic hyperplasia: Prostatic hyperplasia is a benign proliferative disease of the epithelium and mesenchyme of the prostate gland, which can lead to the enlargement and calcification of the prostate gland, which is not a serious problem, and can be treated with drugs such as tamsulosin and finasteride. 3. Prostate cancer: prostate cancer is a kind of malignant tumor that occurs in the prostate gland, which can lead to enlargement and calcification of the prostate gland, which is more serious but can be treated by radical surgery, endocrine and other ways. If the examination found that the prostate gland is enlarged and calcified, it is recommended to consult a doctor in time to find out the cause and follow the doctor’s instructions for treatment. The above medications should be used under the guidance of a professional physician to avoid blind use of medication, so as not to aggravate the condition.