Creatinine 350μmol/L glomerular filtration rate 17ml/min is more serious, and if it is chronic, it usually suggests that the patient enters the stage 4 of chronic kidney disease, and with the development of the disease may be progressed to the stage 5 of chronic kidney disease, i.e. uremia stage. If it is acute, it also suggests that the renal function damage is more serious and needs to be treated actively. The normal value of creatinine is 53~106μmol/L for men and 44~97μmol/L for women in China. glomerular filtration rate is usually between 80~120ml/min. And creatinine 350μmol/L, glomerular filtration rate 17ml/min suggests that the patient’s kidney function is impaired. Staging based on glomerular filtration rate suggests chronic kidney disease stage 4. When the patient’s renal disease develops into chronic kidney disease stage 4, it is necessary to actively treat the primary disease and prevent complications such as renal anemia and metabolic acidosis. As the etiology persists for a long time, it has destroyed the renal tissues, the condition is irreversible, and with the development of the disease, it may progress to uremia, and this period should be prepared for renal replacement therapy. Therefore it is more serious. In addition creatinine 350μmol/L glomerular filtration rate 17ml/min, if acute, also suggests that the renal function damage is more serious, and active treatment is needed. If patients find creatinine increased or glomerular filtration rate decreased, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.