Don’t break the blisters from red fire ant bites. The blisters appeared in red fire ants bite is due to the red fire ants injected certain toxins and bacteria, resulting in allergic reaction and inflammation and infection of the wound. And the skin tissue has a certain resistance to external bacteria and viruses, etc.. Therefore, if the blisters are picked at random, it may lead to further infection of the wound, which may result in the enlargement of the wound, formation of scar or lasting non-healing. Patients are advised to first rinse with cool drinking water and not to apply any medication privately. Afterwards, seek medical advice from a doctor who will use specialized equipment and disinfect the wound thoroughly with iodine povidone. Afterwards, antibiotics or anti-allergy drugs such as fexofenadine hydrochloride tablets and erythromycin ointment should be used as prescribed by the doctor. With professional debridement, the wound will usually improve in a few days. If severe redness, swelling and oozing occur, patients are advised to go to the hospital for further debridement and medication under the doctor’s guidance.