Patients with ear stuffiness and blockage should choose drugs according to different etiologies, and its common causes include cerumen impaction, secretory otitis media, otitis externa, etc.. Glucocorticosteroids such as dexamethasone, antibiotics such as erythromycin, cefuroxime, etc. can be applied according to the different causes and conditions, and some of them need topical medication. 1. Cerumen impaction: Excessive cerumen secretion, blocking the external auditory canal, causing stuffy ears. In this case, no medication is needed, and cerumenolytic agents such as sodium bicarbonate ear drops can be used to soften the cerumen, and the cerumen can be removed by a specialist. 2. Acute secretory otitis media: fluid builds up in the mastoid cavity of the middle ear, causing stuffy ears. For clear bacterial infection, drugs such as erythromycin, cefuroxime and amoxicillin can be taken to control the infection, and glucocorticosteroids such as dexamethasone and prednisone can be taken for anti-inflammatory treatment. 3. Acute diffuse otitis externa: redness and swelling of the external auditory canal, secretion stagnation, causing ear stuffiness and pain. Patients can make the external auditory canal clear, dry and clean at the same time, systemic application of antibiotics to control infection, such as: cefaclor, azithromycin, etc., taking pain relievers, such as ibuprofen. Local application of tampons soaked in 10% ichthyol glycerin wet compress. If the symptoms of ear stuffiness and congestion persist, you can actively consult a doctor for systematic examination and diagnosis, and follow the doctor’s instructions to standardize the use of medication and treatment.