Redness and swelling around the eye of the needle after 13-valent vaccination may be caused by adverse reaction to the vaccine, infection, allergy, etc., which need to be treated by disinfecting the wound and using medication. 1. Adverse vaccine reaction: As the 13-valent vaccine mainly uses attenuated or inactivated pathogenic microorganisms as antigens, it stimulates the human body to produce antibodies, which can lead to redness and swelling around the eye of the needle. This is usually a normal adverse reaction after vaccination, and there is no need to do any special treatment, just take good care of the needle eye. The redness and swelling will gradually disappear with time, usually lasting about three days. 2. Infection: After the 13-valent vaccine, the eye of the needle is infected by bacteria and other pathogens, resulting in inflammation of the eye of the needle and the surrounding area, which can cause redness and swelling around the eye of the needle. The redness and swelling around the eye can be caused by disinfecting the red and swollen area with alcohol or iodophor as prescribed by the doctor. You can also take ampicillin capsules, amoxicillin capsules and other drugs under the guidance of the doctor to play the role of antibacterial and anti-inflammatory. 3. Allergy: After the 13-valent vaccine, allergy to the vaccine or its stimulation of local tissues can lead to an allergic reaction of redness and swelling of the skin around the eye of the needle. This situation can be localized hot compresses to promote skin tissue metabolism. In severe cases, anti-allergy treatment can be given by taking loratadine tablets, cetirizine hydrochloride tablets and other medications as prescribed by the doctor. Redness and swelling around the eye of the 13-valent vaccine needle, need to actively consult a professional doctor, under the guidance of the doctor for examination and treatment, to avoid harm to the body.