Atorvastatin and Rosuvastatin should not be crossed. Although both atorvastatin and Rosuvastatin belong to the statin class of lipid regulating drugs, both are hydroxymethylglutaryl coenzyme A reductase inhibitors, but these two are different drugs, and their specific mechanism of action and metabolic process in the body are different. Atorvastatin and Rosuvastatin should be taken for a long time according to the patient’s specific situation. If they are crossed, it may lead to an increased probability of side effects and not achieve satisfactory lipid regulating effect. Clinically, atorvastatin and resulvastatin are both commonly used statin lipid-regulating drugs, and one of them can be chosen for long-term lipid-regulating treatment, which can stabilize atherosclerotic plaques, regulate blood lipid levels and protect vascular endothelial cells.