Can tacrolimus cause an increase in creatinine?

Tacrolimus has the potential to cause an increase in creatinine, this product is used in the treatment of graft rejection in the liver or kidney, membranous nephropathy, etc., and should be used in accordance with medical advice.
Tacrolimus instructions state that the adverse effects of this product can be seen as abnormal renal function (increased blood creatinine, decreased urine output, increased urea nitrogen), infections, hyperglycemia, diabetes mellitus, headache, tremor, sensory abnormalities, insomnia and so on. Therefore tacrolimus has the potential to cause an increase in creatinine.
Tacrolimus is used for the prevention or treatment of graft rejection (after kidney or liver transplantation) or graft rejection not controlled with other immunosuppression, membranous nephropathy and other diseases.
The drug is contraindicated in people who are allergic to the product, in people who are allergic to other macrolides, and in women during pregnancy.
Tacrolimus should be regulated under medical supervision.