The chromosomal abnormality in the first fetus may or may not be normal in the second fetus, it depends on the situation, if the chromosomal abnormality in the first fetus is due to the genetic inheritance of both parents, the second fetus may be abnormal, if the first fetus is due to the mutation of the fetus gene then the second fetus may be normal. If the parents have abnormal chromosome structure, such as chromosome translocation, inversion, ring chromosome or even chromosome insertion, rearrangement, number change, etc. will lead to chromosome abnormality of the fetus, and the more abnormal part of the genetic material with the parents, the more likely the fetus will be abnormal, if the first fetus is due to this cause of fetal abnormality, then the second fetus also has the risk of fetal abnormality. If the chromosomal abnormality in the first child is due to an abnormality in the fetal chromosomes caused by external factors during gamete formation or division of the fertilized egg or by environmental factors in the pregnant woman’s body, it is more likely that the chromosomes in the second child will be normal. If there must be, genetic counseling is recommended.