Cough and runny nose are mainly clinical manifestations of upper respiratory tract diseases caused by various diseases, mainly including upper respiratory tract infections, and some patients with non-allergic or allergic rhinitis, acute and chronic sinusitis also have similar clinical manifestations. For upper respiratory tract infections, especially for those with common colds, first-generation antihistamines (paracetamol) and decongestants are preferred, and many compounded cold medications contain both, with care taken to avoid repeat dosing, which can lead to drug accumulation and can cause liver function damage. Most are effective within a few days to two weeks. Nasal inhalation of glucocorticoids (e.g., budesonide suspension) and second-generation antihistamines (cetirizine, loratadine, etc.) are preferred for those with allergic rhinitis and provide rapid relief of symptoms. It is also important to avoid and reduce exposure to pathogens. For patients with acute and chronic sinusitis, mostly with purulent nasal discharge and dripping sensation in the throat, cephalosporin or macrolide antibiotics are chosen on the basis of treatment targeting the etiology of the nasopharynx, and also symptomatic treatment with memantine pseudo-anesthetic solution and compound methoxynamine. After treatment for the etiology, the choice of drugs is mainly symptomatic treatment to reduce nasal mucosal congestion and decrease airway hyperreactivity.