Causes of skin abrasion on the sides of the thighs include clothing discomfort, excess fat, fungal infections, and acanthosis nigricans. They should be treated by protecting the wound, losing weight, and using medication. 1. Protecting the wound: If you wear inappropriate clothes, resulting in skin abrasion on both sides of the thighs, you should change the clothes in time, protect the wound, and use iodine povidone to disinfect it. If the trauma is relatively large, sterile gauze should be used to bandage it. 2 Lose weight: If it is due to too much fat in the thighs, it will cause friction when walking, you can lose weight appropriately to reduce leg friction. 3. Use of medication: If it is caused by acanthosis nigricans, you can consider applying hydroquinone and retinoic acid cream externally. Some patients are caused by ringworm, that is, fungal infection, and the commonly applied medications are Butenafine ointment, Ketoconazole ointment and so on. It is recommended that the patient promptly to the hospital, after the cause of the disease is clear, standardized treatment under the guidance of the doctor, the drug should be used under the guidance of the physician, avoid self-medication.