The toxic side effects of Walnut Split Heartwood include digestive reactions, allergies, and heart discomfort. Digestive tract reactions such as nausea, vomiting, and bloating may occur after taking walnut split heart wood. Since it has the effect of promoting bowel movements, patients who are in the period of diarrhea may also aggravate the symptoms of diarrhea and experience frequent diarrhea, which may lead to dehydration in severe cases. People who are allergic to walnut centrifugal wood may also experience allergic reactions, such as skin rashes, itchy skin, etc., and in severe cases, anaphylactic shock may also occur. Some people may experience cardiac symptoms such as tightness in the chest and shortness of breath after taking walnut split heart wood, and this should be observed according to the patient’s condition to see if they need to go to the hospital for treatment. When Walnut Centrum is taken together with the same type of medicine, drug overdose can occur, impairing liver and kidney functions. When Walnut Centrum is taken as a medicinal herb, it should be applied under the guidance of a professional physician to avoid danger and damage to health.