Toe nail folliculitis serious can be cleaned up by medication and surgery, which can help improve the symptoms of the disease and improve the quality of life. 1. Drug treatment: patients with severe toenail fungus infection can rinse the local area with aluminum acetate solution, chlorhexidine solution and so on externally under the guidance of the doctor, or use antibiotic drugs externally, such as mupirocin ointment, fusidic acid cream and so on. Some patients can be injected intramuscular antibiotic drugs, such as ceftriaxone sodium, ceftazidime and so on. 2. Surgical treatment: when non-surgical treatment is ineffective, as well as the recurrence of symptoms, surgical treatment can be taken, such as abscess drainage, nail extraction, etc., so as to control the development of the disease, improve the symptoms of the disease, improve the quality of life. If you have a serious case of onychomycosis, it is recommended that you go to a regular hospital and take relevant treatment measures under the guidance of a doctor to avoid delaying your condition. In daily life, you need to ensure sufficient rest time, do not overwork. At the same time, diet, avoid spicy and stimulating food.