The Chinese medicine identification criteria for viral hepatitis developed are clinically classified as damp-heat accumulation, liver depression and spleen deficiency, liver and kidney deficiency, qi deficiency and blood stasis, and positive deficiency and evil retention. TCM evidence-based treatment of hepatitis C has its specific advantages in liver protection, enzyme lowering, immune adjustment, and anti-fibrosis. The application of interferon and ribavirin in the treatment of hepatitis C, combined with the use of Chinese medicine evidence-based treatment, seeks to enhance the efficacy and reduce side effects. In TCM treatment, the first step is to start with the treatment of depression, which is the depression of liver qi and emotional factors. When the hepatitis virus invades the liver, it affects the patient’s liver qi drainage, which is the pathological basis of hepatitis C. Secondly, we have to start with dampness, because hepatitis C is considered a “damp-heat and epidemic poison” disease in Chinese medicine. It has been found that damp-heat blockage is the main clinical evidence of hepatitis in TCM, so Artemisia Inchi Tang is a common formula for hepatitis C. According to TCM, dampness is sticky and lingering, which is responsible for the prolonged course of hepatitis C. In patients with chronic hepatitis C, symptoms of spleen and stomach such as weakness, poor appetite, stuffiness and abdominal distension are seen, and deficiency evidence is common; according to TCM, liver is wood and spleen is earth, and liver disease is known to damage the function of the spleen and stomach, and with poor spleen and stomach function, the patient will suffer from malabsorption of nutrients, which naturally affects the liver. Chinese medicine treatment of hepatitis C mainly starts from depression, dampness and deficiency, commonly used Chinese herbal medicines Yin Chen, Gardenia, Rhubarb, Pendula, Panax, Poria, Atractylodes, Radix Codonopsis, Astragalus and Dates.