The treatment of 90% stenosis of anterior descending branch includes lifestyle adjustment, drug therapy, coronary artery blood flow reconstruction and so on. 1. Lifestyle Adjustment: With 90% stenosis of anterior descending branch near the middle, i.e. clear diagnosis of coronary artery disease, it is important to pay attention to lifestyle adjustment, such as paying attention to light diet, quitting smoking and restricting alcohol, reducing the mental burden, and appropriate activities. 2. Drug therapy: the drugs used in the treatment of coronary heart disease include antiplatelet drugs such as aspirin, clopidogrel, etc.; lipid-lowering drugs such as atorvastatin, resuvastatin, etc.; and drugs to improve the symptoms of cardiac ischemia, such as metoprolol and bisoprolol. 3. Coronary artery revascularization: 90% stenosis of anterior descending branch near the middle, generally need coronary artery revascularization, the way of percutaneous coronary intervention, coronary artery bypass grafting. The choice of the specific modality needs to be considered by a specialized physician based on the condition of the coronary artery lesion and the patient’s tolerance level of open-heart surgery and the patient’s hospital. When the coronary artery stenosis is found, it is recommended to consult a doctor in time and carry out standardized treatment under the guidance of a professional physician, and avoid unauthorized treatment to avoid adverse consequences.