Lung adenocarcinoma advanced bone metastasis with pleural fluid may be due to hypoproteinemia, tumor invading into pleura, etc. It can be improved by actively treating the primary disease, closed drainage of thoracic cavity or infusion of albumin. Lung adenocarcinoma with advanced bone metastasis has hydrothorax, which is cancerous hydrothorax caused by lung adenocarcinoma invading the pleura and spreading widely on the pleura, which increases the permeability of the capillaries on the surface of the pleura and then produces cancerous hydrothorax, and it needs to be treated by targeting at lung adenocarcinoma of the primary disease, and it can be treated by chemotherapy, and it can be treated with drugs such as Docetaxel, cisplatin, bevacizumab, gefitinib and so on. Closed thoracic drainage can directly drain out the pleural fluid, which can directly alleviate the symptoms of dyspnea due to pleural fluid; moreover, due to the consumption of the tumor on the patient, patients with advanced stage can have hypoproteinemia, which causes an increase in the production of pleural fluid, and the hypoproteinemia can be improved by the infusion of albumin, which can in turn alleviate the symptoms of pleural fluid. If diagnosed with lung adenocarcinoma advanced bone metastasis with pleural fluid, please follow the doctor’s instruction for treatment.