Lidocaine is an important class of amide local anesthetic, widely used in important clinical medical fields, according to its molecular structure can be found that lidocaine penetration and the molecular structure is also affected by temperature changes, the specific explanation is as follows. 1. Strong penetration: the amide bond in the molecular structure of lidocaine is more stable than the ester bond, and there are two methyl groups adjacent to the amide group, forming a spatial water-blocking effect, so that it is more stable to acid and alkali, not easy to hydrolyze, and the speed of enzymatic digestion in vivo is also slower, and compared with procaine, it is strong in penetration and has a fast onset of action. 2. Affected by temperature: there are various infrared absorption modes of lidocaine molecules, with the increase of temperature, the absorption frequency and intensity corresponding to the main functional groups of lidocaine molecules are changed to some extent. Lidocaine is an injectable drug that needs to be injected and used by a doctor, do not use it privately to avoid life-threatening situations.