During the follicular phase of the normal menstrual cycle, the average serum testosterone concentration is 0.43 ng/ml, with a high limit of 0.68 ng/ml. If it exceeds 0.7 ng/m1 (equal to 2.44 nmol/L), it is called hypertestosteronemia, or hyperandrogenemia. The ovaries and adrenal cortex can synthesize cholesterol from acetic acid or absorb cholesterol from the blood as a substrate to synthesize steroid hormones, which are secreted into the blood circulation. The main androgens in the blood circulation are dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (Δ4A), testosterone (T) and dihydrotestosterone (DHT). Hypertestosteronemia is the result of high levels of these hormones, especially testosterone, in the blood. Prevention and treatment of significantly elevated serum testosterone concentration: 1. Spironolactone Spironolactone can compete with androgens, especially dihydrotestosterone (DHT), for receptors on target cells, interfering with the formation of normal dihydrotestosterone, and also inhibiting the activity of some enzymes, interfering with the biosynthesis of testosterone. In the 5th to 21st d of menstrual cycle, 100mg/d for 4-6 cycles, LH and T can be reduced to normal level after stopping the drug, while FSH and PRL have no change compared with before treatment. Side effects such as polyhydramnios, polyuria, fatigue, headache, etc. are few and mild and do not require discontinuation of the drug. 2.Corticosteroids such as Prednison 5mg, 2/d; Dexamethasone 0.5~0.75mg, 2/d, all taken continuously for 3-6 months. The greatest effect of corticosteroids is to suppress adrenal cortical function, resulting in a decrease in the secretion of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), androstenedione (Δ4A) and testosterone (T). Therefore, it is indicated for hypertestosteronism of adrenal origin. The ovulation rate of this product alone is ≥50%; if combined with clomiphene, the ovulation rate can reach 80%-100%. 3.Clomiphene can block the abnormal metabolism of steroid hormones. 50-100mg, 1/d, starting from the 5th day of menstruation for 5 d, to promote follicle maturation, ovulation and formation of corpus luteum. Ultrasound monitoring of follicle growth from the 8th day of menstruation. When the maximum diameter of the dominant follicle reaches 18mm, a single intramuscular injection of chorionic gonadotropin (HCG) 5000U can more effectively assist in promoting ovulation and prevent luteal insufficiency in some patients. 4.Urinary gonadotropin can improve the activity of aromatase, and promote the conversion of androstenedione to estrone and testosterone to estradiol. It is commonly used as human menopausal gonadotropin (HMG). 1~2 injections (150~300U) daily starting from the 5th day of menstruation, until the maximum diameter of the dominant follicle reaches 18mm, stop using HMG and inject another 5000U of HCG to stimulate ovulation. The special pure follicle maturation hormone (Metrodin) contains only FSH and is more suitable. Starting from the 5th day of menstruation, inject 75U intramuscularly once a day until the 8th day of menstruation, monitor follicle growth by ultrasound, and when the maximum diameter of the dominant follicle reaches 18mm, stop injecting Metrodin and inject another intramuscular injection of HCG 5000U to stimulate ovulation. 5. Paeonia lactiflora and Glycyrrhiza glabra soup can reduce T value, convert T into E2, increase FSH/LH ratio and make TEBG concentration rise. 7,5g of mixed powder of Paeonia lactiflora and Glycyrrhiza glabra is taken once a day. 12g each of Paeonia lactiflora and Glycyrrhiza glabra is decocted and drunk as tea, one dose is taken daily for 3 to 4 months continuously with the same effect. The combination of peony and licorice soup with clomiphene or prednisone can improve ovulation rate and conception rate. 6.Chinese medicine artificial cycle therapy Lin Zhijun treated 27 cases with the above artificial cycle therapy, 15 cases were pregnant within six months and 24 cases within three years after treatment. Fan Youping divided the symptoms of hypertestosteronism into 4 types: kidney deficiency, blood stagnation, phlegm-dampness obstruction, and liver stagnation and fire. 45 cases were treated with GUI Kidney Tang, Blood Mansion and Blood Stasis Soup, Cang Fu Gui Phlegm Soup, and Gentian Diarrhea Liver Soup with addition and subtraction.