The blood vessels of different organs can be involved. If the heart vessels are sclerotic there will be coronary heart disease with a risk of acute myocardial infarction; cerebral atherosclerosis with a risk of stroke; renal atherosclerotic stenosis with possible intractable hypertension and long-term stenosis with possible renal insufficiency; and progression of atheromatous plaques in the extremities with corresponding limb claudication and ulceration.