The chances of a biopsy of a gastric angle ulcer being benign are uncertain. Gastric angle ulcers are a type of gastric ulcer, and all gastric ulcers have the potential to become cancerous. When gastroscopy reveals a gastric ulcer, it is important to differentiate it from a malignant ulcer. Gastroscopy combined with biopsy is helpful to clarify benign and malignant ulcers and whether cancer has occurred. Typical gastric ulcers are found near the gastric angle and the side of the small curvature of the gastric sinus. Most of the active ulcers are less than 10mm in diameter, with regular edges, and the surrounding mucosa is often congested and edematous, and the surface of the ulcers is covered with white moss or yellow moss, with granulation tissues at the bottom. Some gastric ulcers are difficult to distinguish benign and malignant under gastroscopy, and require multiple biopsies and pathologic examinations. Typical gastric cancer ulcers are irregular in shape, larger than 2cm in size, with nodular margins, uneven bottom, covered with dirty moss, and easy to bleed during biopsy. If the disease is diagnosed, it is recommended that patients should undergo standardized treatment as early as possible in order to reduce the adverse effects of the disease.