The third shot currently refers to the third shot of the New Crown vaccine. Whether or not a thyroid nodule can receive the third shot of the vaccine depends on the patient’s condition; if it is just a simple thyroid nodule, the third shot is usually allowed. If the patient is accompanied by hyperthyroidism or hypothyroidism, the third shot is not recommended for the time being and should be given after the condition is stabilized. Thyroid nodules are masses formed by localized abnormal proliferation of thyroid cells. Most thyroid nodules are benign and can be vaccinated with the third injection if there are no other symptoms. If the patient has symptoms of hyperthyroidism or hypothyroidism, such as generalized weakness, panic, sweating, etc., then do not take the third injection for the time being, and vaccinate at a later date after the condition is stabilized. After vaccination, if there is any discomfort, it is recommended to consult a doctor promptly.