The four-year-old child fever rash may be streptococcal infection, rubella, measles, chickenpox, etc., can be rest, cooling, antiviral, anti-bacterial infections and other treatments. 1. Streptococcal infection: children with fever rash after a common streptococcal infection resulting in a generalized diffuse red rash, the need for timely medical treatment with penicillin (such as amoxicillin) medication, penicillin allergy can be used cefuroxime sodium, etc., and pay attention to rest, symptomatic treatment. 2. Rubella: Rubella virus, mostly on the second day of fever rash and out within one day, we should pay attention to bed rest, give nutritious and easy to digest food, and give symptomatic treatment, fever to be physical cooling, if necessary, to be medicated to lower the temperature (eg, ibuprofen) and so on. 3. Measles: Measles virus, mostly in fever 3~4 days after the rash, and the rash for the peak of fever, need to pay attention to rest, high fever can be given antipyretic (such as acetaminophen). 4. Chickenpox: Chickenpox and maculopapular rash appear after 1~2 days of fever, it is a kind of infectious disease, need to isolate, pay attention to hygiene, strengthen care. Children’s disease with rash may have many diseases, need to go to the hospital in time to find out the cause of the disease, and actively cooperate with the doctor’s diagnosis and treatment. The use of medication should follow the doctor’s instructions.