Zhi Bai Si Wu Tang (知柏四物汤) has the efficacy of nourishing yin and lowering fire (nourishing yin essence and lowering fire), regulating menstruation and harmonizing blood. Zhi Bai Si Wu Tang (知柏四物汤) is a traditional Chinese medicine formula composed of Zhi Mu (知母), Huang Bai (黄柏), Angelica sinensis (当归), Radix Rehmanniae Praeparata (生地黄), Rhizoma Ligustici Chuanxiong (川芎), and Radix Paeoniae Alba (白芍), which is known for nourishing yin, lowering the fire, regulating the menstruation and harmonizing the Blood. Its combination is characterized by using Si Wu Tang to harmonize Blood and nourish Blood, with Huang Bai and Zhi Mu to clear heat and nourish Yin. Adverse effects of this formula are not known. It should be noted that this formula is contraindicated in those who are allergic to the ingredients of this formula, and should be used with caution in those with allergy, cold blood, and menorrhagia in the late stage of menstruation. If this formula is to be used, it should be used under the guidance of a physician, and should not be used blindly on its own to avoid causing adverse reactions.