Dampness with cracks on the buttocks can be caused by sedentary behavior, eczema, and anal fissures. It can be improved by topical ointment and surgery. 1. Sedentary: Long-term sedentary will lead to moist buttocks and cracks may appear in constant friction. Some ointments can be applied under the guidance of a doctor to help improve the situation, such as erythromycin ointment, and patients should avoid sitting for a long time in their lives. 2. Eczema: Eczema is a common inflammatory skin disease of the epidermis and superficial dermis caused by a variety of factors, and there may be cracks in the moist buttocks. It can be improved by topical glycerine lotion under doctor’s guidance, or dexamethasone ointment, florazepam ointment and so on. 3. Anal fissure: Anal fissure refers to the cracking of the whole skin around the anus, and the fissure will secrete sticky secretion, which will flow out of the anus and may cause moist buttocks. It can be treated by applying nitroglycerin cream under the guidance of a doctor, and at the same time using anal fissure excision and other related surgical methods for treatment. It is recommended that patients with moist buttocks with fissures should go to regular hospitals in time to find out the cause of the disease and choose targeted treatment under the guidance of professional doctors.