The effect of nifedipine on men can be manifested as erectile dysfunction, as well as nosebleeds, dyspepsia, vertigo, muscle spasms, etc., so it should be standardized under the guidance of a doctor. Nifedipine is a calcium antagonist, can specifically act on cardiomyocytes, smooth muscle cells of peripheral resistance vessels, etc., with the effect of lowering blood pressure, mainly used in the treatment of hypertension, coronary heart disease. The effect on men can be seen in penile erectile dysfunction, mostly due to the reduction of smooth muscle tone, but the incidence is small, once found should immediately stop the drug, and seek medical attention. Adverse reactions such as nosebleeds, dyspepsia, dizziness, muscle spasms, polyuria, and nonspecific pain can also occur during nifedipine administration, with no difference in incidence between men and women. Allergy to nifedipine, cardiogenic shock, KOCK vesicles, pregnant and lactating women should be prohibited. In conclusion, nifedipine should be used under the guidance of a physician or pharmacist.