There is no doubt that cranial defects can cause a number of hazards for patients. Fortunately, cranial repair can restore the integrity of the skull, restore the original appearance, and resolve the various problems it causes. Cranial repair has been developed and perfected over decades, and has a complete system of perioperative management protocols that provide ideal results. However, some people may have some postoperative complications, such as rejection and infection, after common skull repair. Once these conditions occur, the first reaction given by the patient is that the skull repair was not done properly. Is rejection after cranial repair not a good surgery? There are two main reasons for rejection after cranial repair, one is related to the individual’s constitution and immune system, and the other is the poor compatibility of the chosen repair material with oneself, which causes rejection. Titanium mesh is a common cranial repair material, although it has certain repair effect, but because of the metallic characteristics, the heat insulation performance is poor, and the patient will be very sensitive to the external hot and cold environment after surgery, which will bring a lot of discomfort to the patient. This kind of material is not hard enough, and it is easy to collapse after surgery because of the impact of external force; there will be infection and rejection after surgery, and it will even lead to the damage of scalp tissue and the direct exposure of titanium mesh material. Therefore, patients must think twice before choosing skull repair materials. In recent years, a new peek material is used clinically, which is a very advanced material with high hardness, good protection performance and ideal shaping effect, in a word, all the properties are better than titanium mesh, which can be a great blessing for patients with skull defect. In recent years, our trauma neurosurgery team has borrowed the concept of cosmetic surgery and carried out peek cranioplasty, which can precisely repair the defective parts through 3D reconstruction and 3D printing technology to achieve the dual effects of complete and symmetrical skull and aesthetic appearance, bringing well-being to many patients with cranial defects and winning good reputation from patients.