Children with problems manifest themselves in the following ways: First, in early childhood, patients may experience growth retardation, such as being shorter than their peers in height, speaking and walking later than their peers, and also having straightened eyes. Second, if a child has a problem in adolescence, he or she will show a decrease in academic performance and social activities. The child may have difficulty concentrating in school, have significantly poorer academic performance than children of the same age, exhibit aggressive behavior, become overly excited, and have no control over their activities. Some may also be aggressive, have recurrent seizures or persistent epilepsy, and walk uncoordinated, all of which are specific signs that the child has a problem.