There is no such thing as a nemesis for whooping cough. Antibiotics are usually given for whooping cough, and macrolides such as erythromycin and roxithromycin are commonly used. Pertussis is an acute respiratory infection caused by Mycobacterium pertussis. Patients present with paroxysmal, spasmodic cough with no or little sputum, accompanied by a chicken-like roar at the end of the cough, and the cough tends to be prolonged, and the duration of the disease can be as long as 1-3 months. The application of antibiotic drugs in the treatment of pertussis is very critical, preferred macrolides, such as erythromycin, roxithromycin. However, some patients are resistant to macrolides, in which case the treatment effect is less satisfactory, and antibiotics can be selected according to the drug sensitivity test. For patients whose cough causes wheezing and dyspnea, intramuscular injection of small doses of adrenocorticotropic hormone, such as dexamethasone, can reduce symptoms and shorten the duration of the disease, but must pay attention to the possible side effects of the drug, which must be used in accordance with medical advice. Intramuscular pertussis immunoglobulin may also be given to infants and young children in severe cases. Use the medication as prescribed by your doctor. When considering whooping cough, it is recommended to consult a doctor and follow medical advice. The above medications should be used under the supervision of a physician.