The treatment of lung squamous cancer with advanced bone metastasis is comprehensive treatment with chemotherapy, immunotherapy and targeted therapy. 1. Chemotherapy: When bone metastasis occurs in squamous lung cancer, cisplatin, carboplatin, paclitaxel and other drugs can be chosen for chemotherapy according to medical advice. At the same time, supportive treatment should be given, and nausea, vomiting, pain and other discomforts caused by chemotherapy should be treated symptomatically. 2. Immunotherapy: PD-1 or PDL-1 monoclonal antibody can be used in combination with chemotherapy as prescribed by doctors for advanced bone metastasis of squamous lung cancer to slow down the progress of the disease. 3. Targeted therapy: Targeted therapeutic drugs such as amilorotinib and apatinib can hinder angiogenesis and achieve the effect of treating advanced bone metastasis of squamous lung cancer. When advanced bone metastasis of squamous lung cancer occurs, one should consult a doctor in time and choose the appropriate treatment method after examination and evaluation by a doctor to avoid delaying the condition.