tp53 mutation generally refers to TP53 gene mutation, clinically there is no targeted drugs for the treatment of TP53 gene mutation, it is recommended that patients combine their own situation, ask the doctor’s guidance. TP53 is a tumor suppressor gene, mainly used to regulate the proliferation of tumor cells. When a patient has a mutation in TP53 gene, it means that the tumor suppressor function is lost, which will result in the uncontrolled proliferation of tumor cells. Currently, there are no targeted drugs for the treatment of TP53 gene mutation. There are many types of diseases with TP53 gene mutation, such as liver cancer, cervical cancer, lung cancer and so on. Patients with TP53 gene mutation need to pay attention to this kind of diseases, and it is recommended to go to regular hospitals in time, take into account their own conditions and personal needs, and actively cooperate with doctors to take treatment measures, so as to avoid delaying the condition. During the treatment period, patients with TP53 gene mutation should also maintain sufficient rest time and do not overwork.