High indirect bilirubin may be caused by cirrhosis, viral hepatitis, hemolytic anemia, etc. It can be relieved and treated by reducing alcohol intake, adequate rest, use of glutathione, lamivudine, glucocorticosteroids and other medications and surgery.
1. Cirrhosis: liver cells of patients with cirrhosis have different degrees of damage, and there are different degrees of obstacles to bilirubin binding, excretion, uptake and other processes, thus leading to high indirect bilirubin, which can lead to yellowing of the skin, sclera and other parts of the body, i.e., hepatocellular jaundice, which can be treated by taking medicines such as entecavir, glycyrrhizin, glutathione, etc., and liver transplantation can be performed if necessary.
2. Viral hepatitis: patients with viral hepatitis have weakened excretion, uptake and metabolism of indirect bilirubin due to the damage of hepatocytes, which elevates indirect bilirubin in serum. They should have sufficient rest, avoid overwork and intake of food such as alcohol; interferon, lafminidine, sofosbuvir and other drugs can be used for antiviral treatment, and surgery is feasible when necessary.
3. Hemolytic anemia: a large number of red blood cells in patients with hemolytic anemia have been destroyed, resulting in the formation of a large amount of indirect bilirubin, which exceeds the upper limit of hepatic uptake and binding, thus causing an increase in serum indirect bilirubin. Treatment with glucocorticoids, cyclophosphamide and other drugs can be used, and splenectomy and allogeneic hematopoietic hepatocyte transplantation can be chosen if necessary.
Patients with high indirect bilirubin are advised to consult a doctor for a clear diagnosis and targeted treatment. In addition, all of the above drugs should be used under the guidance of a doctor and should not be used without authorization.