The common symptoms of HFMD are fever, oral pain, and rash on the hands, feet, and buttocks. Parents are often very anxious because children’s conditions change rapidly and they cannot express their condition, and children from 6 months to 5 years old can have convulsions during the high fever period. The following are answers to some of the questions that parents are often concerned about. 1. Do I have to use antibiotics for fever? Many parents ask their doctors to use antibiotics directly after admission, but in fact, 90% of common colds are caused by viruses and are self-limiting diseases, so antibiotics are not recommended. Unless there is a clear combination of purulent tonsillitis, otitis media, sinusitis and other bacterial infections, then antibiotics can be given. 2.Do I have to get an injection or infusion for fever? Although injections are effective, they can have side effects. At present, the main fever-reducing injections for children are pyrazolones, such as Anadrol and Advil. These drugs have large side effects and can easily cause complications such as deficiency, hip muscle damage, infection and even hip muscle atrophy or paralysis, so it is advisable to use these injections with caution. 3.Does the fever need to be reduced immediately? Some parents ask the doctor to reduce the fever immediately when they see their child has a fever, but in fact there is no danger of low to moderate fever itself. Studies have shown that the brain is only damaged when the body temperature exceeds 41.3°C. The body’s immune system can function better at 37.5°C-38.5°C. In this case, reducing the fever may prolong the course of the disease, but the fever needs to be reduced when the child has febrile convulsions, is extremely weak or has severe pulmonary heart disease. In addition, fevers in children within 2 months of age are mostly caused by infections, so in principle, antipyretic drugs are not used to avoid neglecting the judgment of the infected condition due to antipyretic. 4.How to choose the method to reduce fever? Fever reduction methods include conventional care (drink more water, keep the room air circulation and environment cool, take off more clothes), physical cooling (ice bag cooling, alcohol bath, warm water bath) and medicine to reduce fever. Low to moderate fevers often do not require medication to reduce fever, but only routine care and physical cooling. High fever with chills or with sweating is not suitable for alcohol baths, and it is forbidden to rub the front of the face, abdomen, soles of the feet, precordial area, behind the occiput, auricle, scrotum, in addition to alcohol baths have greater side effects on young children, so warm water baths are the best way to physically cool infants and children. In case of high fever, medication can be given to reduce fever. 5.How to choose antipyretic drugs? There are four major classes of clinical antipyretic and anti-inflammatory drugs: salicylates (such as aspirin), anilines (such as acetaminophen), pyrazolones (such as aminopyrine) and other anti-inflammatory organic acids (such as anti-inflammatory pain and ibuprofen). Aspirin adverse reactions include gastrointestinal reactions, coagulation disorders, allergic reactions, salicylic acid reactions, and Reye’s syndrome, and is therefore contraindicated in patients with asthma, allergies, and viral infections. Acetaminophen adverse reactions are relatively rare and can be seen as allergic reactions, drug fever, methemoglobinemia, interstitial nephritis, liver damage, and hemolytic anemia. Aminophenazone adverse reactions include gastrointestinal reactions, sodium retention, allergic reactions, hepatic and renal damage, goiter, and mucinous edema. Adverse reactions to anti-inflammatory pain include gastrointestinal reactions, central nervous system reactions, allergic reactions, and suppression of the hematopoietic system, and are therefore prohibited in children. The World Health Organization currently recommends the safest and most effective tablets or oral solution made from acetaminophen as a raw material. Children in early childhood and adolescence should never use aspirin to reduce fever, so as not to leave sequelae. 6.How do I eat when I have a fever? Under normal circumstances, the body metabolism increases by 13% when the body temperature rises by 1 degree, so when children have fever, their nutritional consumption increases. At the same time, the function of the gastrointestinal tract is weakened, gastrointestinal peristalsis slows down, and the secretion of digestive juices decreases, which can cause loss of appetite, diarrhea or constipation and affect absorption, so regulating the diet helps the recovery of the disease. Children have a high proportion of body fluids and poor organism regulation, so they are prone to disorders of water, electrolytes and acid-base balance, because the body loses a lot of water and electrolytes through sweating and heat dissipation during fever. During the acute period, we recommend giving liquid diet, such as milk (diluted with water or rice soup as appropriate), rice soup, mung bean soup, fresh fruit juice, and during the recovery period, we can give semi-liquid diet, such as meat porridge, noodles and other easily digestible food, avoiding overfeeding, and avoiding seafood, greasy, cold drinks and spicy and stimulating food. In short, fever is not terrible, it is the performance of the body’s immune response, do not need to be overly panic about fever.