Mesothelioma is a tumor derived from mesothelial cells. The role of mesothelial cells is to provide lubrication so that organs are well protected from each other and from organs to pleura and peritoneum, so mesothelial cells are mainly located on top of pleura and peritoneum. Mesothelioma is a tumor that originates in the pleura and peritoneum. It is usually believed that the occurrence of mesothelioma is related to environmental factors such as exposure to asbestos, and can be divided into benign mesothelioma and malignant mesothelioma, which produce different symptoms depending on the site of occurrence. The main symptoms produced by mesothelioma in the chest are chest pain, difficulty in breathing, and weight loss. The main symptoms of abdominal mesothelioma are abdominal pain, bloating, ascites, and abdominal masses. The diagnosis of mesothelioma is mainly based on clinical manifestations, physical examination as well as ultrasound, CT and pathological examination, etc. The treatment methods mainly include surgery, chemotherapy and radiotherapy, etc.