There are many reasons for coughing at 2 o’clock in the middle of the night, which may be caused by dryness of the respiratory tract, inhalation of allergic substances, gastroesophageal reflux disease and other reasons. 1. Respiratory tract dryness: Sometimes people are seriously dehydrated when they go to bed, or the house is particularly dry, which can cause respiratory tract dryness and irritation, and can also cause coughing and other symptoms. 2. Inhalation of allergic substances: when people sleep at night, many due to open doors and windows, easy to drift into some dust, pollen and special gases, etc., to stimulate the human respiratory tract, which in turn cause cough in the middle of the night. 3. Gastroesophageal reflux disease (GERD): a chronic disease in which the contents of the stomach and duodenum reflux into the esophagus, resulting in a series of symptoms. Sleeping in a flat state, acidic reflux may reflux to the throat, stimulating the throat, trachea, causing coughing, pharyngeal discomfort and other symptoms. Its can cause 2 o’clock cough in the middle of the night. There are many reasons for coughing at 2 o’clock in the middle of the night, you should go to the hospital in time to clarify the cause of the disease, and under the guidance of the doctor for treatment.