Nifedipine and Irbesartan are common antihypertensive drugs, the mechanism of action of these two drugs is completely different, can be used in combination, reasonable control of blood pressure, reduce the adverse effects of drugs.
1. Irbesartan is an angiotensin II receptor antagonist, and there are also valsartan and chlorosartan in this class of drugs. Its target is the angiotensin receptor, and after acting on this target, it can inhibit vasoconstriction and achieve the effect of lowering blood pressure.
Adverse effects of Irbesartan include headache, palpitations and cough. Irbesartan is contraindicated in women in the 4th to 9th month of pregnancy and lactating women.
2. Nifedipine is a calcium antagonist. It can inhibit the inward flow of calcium ions in the endothelial cells of blood vessels, causing vasodilation and lowering peripheral vascular resistance, thus lowering blood pressure.
Adverse reactions to nifedipine include dizziness, headache, and facial flushing. It is contraindicated in patients who are allergic to nifedipine.
The combination of these two drugs can significantly reduce blood pressure. For patients with persistent hypertension, the guidelines for the management of hypertension recommend the combination of these two drugs to lower blood pressure, and also to reduce the occurrence of drug resistance.