Pulmonary blisters are also known as pulmonary macules. Pulmonary blisters are irreversible pulmonary changes that are often detected during chest imaging in patients with emphysema. In small solitary pulmonary blisters, the patient has no obvious discomfort, no special treatment is needed, and the blister can become larger in some patients with regular observation. However, for huge pulmonary blisters or multiple large pulmonary blisters, the patient’s lung function may be affected and the patient may experience shortness of breath and discomfort after activity. Some patients with huge pulmonary blisters, especially those near the periphery of the lungs, can rupture and form a pneumothorax due to coughing, strenuous activity and lifting heavy objects. In this case, patients mostly need to perform closed chest drainage and suction treatment. Pneumothorax on the lung is a benign lesion and should not cause concern, but should be actively treated for existing emphysema disease. For huge pulmonary blisters or pneumothorax formed by rupture of pulmonary blisters, surgical repair and resection can also be performed to achieve the purpose of radical treatment.