The time of recurrence of gastrointestinal mesenchymal stromal tumors after surgery is uncertain, ranging from a few months to several years, and is related to factors such as the size of the tumor, risk classification, and the degree of surgical eradication. Specific needs to be analyzed according to the condition. Gastrointestinal mesenchymal tumors are the most common mesenchymal tumors in the digestive tract, originating from receptor mutations expressed by mesenchymal cells. Clinical manifestations include abdominal pain, vomiting blood, black stool and abdominal mass. 1. Tumor size: the larger the diameter of the tumor, the higher the rate of postoperative recurrence and metastasis, and the lower the survival rate. 2. Risk grade: the higher the risk grade, the higher the chance of recurrence and metastasis after surgery and the lower the survival rate. 3. degree of surgical cure: whether the tumor is completely resected or not during surgery, whether it is ruptured or not during surgery and operation all affect the chance of recurrence. In principle, gastrointestinal mesenchymal tumors should be treated with surgery, combined with targeted drug therapy as the main comprehensive treatment. If the mesenchymal tumor volume is small, surgery should be the first choice, but the mesenchymal tumor volume is large, accompanied by extensive invasion and metastasis, at this time, targeted therapy should be the mainstay of treatment, and then surgical treatment should be performed at a later stage. After surgery for gastrointestinal mesenchymal tumor, following the medical advice to take medication on time, regular review, and maintaining a healthy lifestyle plays an important role in prolonging life.