The duration of coma in the advanced stage of liver cirrhosis is variable, depending on the condition, it can gradually develop from drowsiness to light coma and deep coma. In the advanced stage of liver cirrhosis, due to the decline of liver detoxification function, toxin accumulation, affecting the excitability of central nervous system, i.e., the emergence of hepatic encephalopathy, which can lead to drowsiness, coma, etc., and active treatment, can wake up after a few days, serious coma, and life-threatening. In the advanced stage of liver cirrhosis, in addition to coma, ascites, portal hypertension, spider nevus, jaundice, etc., need active treatment. Treatment of advanced cirrhosis, commonly used drugs for liver protection drugs and blood ammonia-lowering drugs, such as reduced glutathione tablets, Mentholatum ornithine, ursodeoxycholic acid tablets and so on. Daily life, pay attention to protect the liver, quit smoking and drinking, light diet, low salt and low fat diet. Cirrhosis patients need to consult the doctor in time, follow the doctor’s instructions for treatment and regular review in order to slow down the progression of the disease.