Cardiac neurosis should involve medical psychology and psychiatry specialists in treatment or consultation. Psychotherapy can be supplemented with medication to treat the associated mental and physical symptoms. Treatment begins with relieving the patient’s anxiety, relaxation, and adequate sleep. Medications to improve anxiety or depression are the first-line drugs commonly used to treat cardiac neurosis, such as citalopram, paroxetine, fluvoxamine, and melitrexin are available. Smaller doses of sedative drugs such as diazepam and eszopiclone are also available for short-term use as appropriate. For hypercardiovascular symptoms, such as combined tachycardia, metoprolol can be applied in small doses to slow down the heart rate. Metoprolol has central nervous system adverse effects. If insomnia or insomnia is aggravated, non-fat soluble preparations such as atenolol may be used. Patients with cardiac neurosis who are in a state of chronic tension and anxiety, often combined with dyspeptic symptoms, can be treated with gastrointestinal regulating drugs, such as azelastine medication. When the efficacy is achieved, treatment should not be stopped immediately, as it may easily cause relapse and also bring psychological concerns and even loss of confidence to the patient. The treatment should be maintained for more than 3 to 4 months, then gradually reduce the dosage and slowly stop the medication, so as to avoid sudden discontinuation of medication causing “discontinuation syndrome”. All the above mentioned drugs should be taken under the guidance of a specialist, and patients should not use them on their own.