There is no absolute most suitable drug for high blood pressure, and comprehensive treatment should be given according to the condition, and currently diuretics, beta-blockers, calcium channel blockers and other drugs can be used for treatment. 1. Primary high diastolic blood pressure: (1) Diuretics, such as hydrochlorothiazide, spironolactone, etc., can be used, which are prohibited for patients with gout. β-blockers, such as propranolol, metoprolol, etc., are prohibited for patients with acute heart failure. Calcium channel blockers, such as nifedipine, amlodipine, etc., can have adverse effects such as increased heart rate. (2) Angiotensin-converting enzyme inhibitors, such as captopril, enalapril, etc., are contraindicated in pregnant women and patients with hyperkalemia. Angiotensin II receptor antagonists, such as chlorosartan and irbesartan, are contraindicated in women with bilateral renal artery stenosis and during pregnancy. 2. Secondary increase in diastolic blood pressure: caused by pheochromocytoma, it is recommended to use α and β receptor antagonists, common drugs are bisoprolol, phentolamine, tolazoline and so on. 3. Hypertensive crisis: sodium nitroprusside, nitroglycerin, nimodipine, labetalol and other drugs are recommended for treatment. The above drugs are recommended to be used under the guidance of a doctor. When high low blood pressure occurs, it is recommended to go to the hospital in time to find out the cause and treat it in time so as not to miss the condition.