High-grade intraepithelial neoplasia of the intestine undergoes lymphatic metastasis. Intraepithelial neoplasia is a descriptive term for pathologic testing that can have the potential for malignant transformation, and common routes of metastasis include direct spread, bloodstream metastasis, and lymphatic metastasis. 1. Direct spread: high-grade intraepithelial neoplasia of the intestine, if malignant, can spread directly to the surrounding organs, such as the peritoneum, anus, female reproductive organs, male reproductive organs, bladder and so on. 2. Bloodway metastasis: high-grade intestinal intraepithelial neoplasia turns if it is malignant tumor, it can carry out bloodway metastasis and transfer to lungs, liver, stomach, and other organs. 3. Lymph node metastasis: it is the most common metastatic pathway of intestinal high-grade intraepithelial neoplasia and also the primary metastatic pathway. If the patient’s physical examination is intestinal high-grade intraepithelial neoplasia, it is recommended to go to the Department of Surgery or Gastroenterology in time to avoid delay.