Nucleic acid test generally refers to the new coronavirus nucleic acid test, which can be done with a cold and fever. Doing a nucleic acid test when you have a cold and fever does not affect the amount of virus in your body fluids, and it usually does not interfere with the results of the test, and the final results of the test are also more accurate, so it will not affect the results of the nucleic acid test. If the test report is positive after the nucleic acid test for cold and fever, it means that there is a pathogen infection in the body. It is recommended that patients with cold and fever try not to eat for 2 hours before the nucleic acid test, and not to smoke, drink or chew gum for the first 30 minutes so as not to affect the accuracy of the results. If a cold and fever show a positive result in the nucleic acid test, you should actively cooperate with your doctor for treatment.