The treatment of patients with stage II malignant melanoma is mainly surgical treatment, and some patients should consider combined postoperative adjuvant therapy. Malignant melanoma is a tumor disease with high degree of malignancy, which occurs in the foot, nasal mucosa and other parts of the body, and the treatment method is mainly based on surgical treatment. Stage II patients are usually treated with surgical resection of the primary tumor lesion, accompanied by ulcers and tumors with large thickness are usually performed at the same time with sentinel lymph node biopsy.Stage IIB patients are recommended to undergo postoperative adjuvant therapy, such as the use of high-dose α-2b interferon, to reduce the risk of tumor recurrence and prevention of metastasis. Once diagnosed, melanoma should be treated promptly. Overall, the earlier the detection and the more timely the treatment, the better the prognosis.