Si Shen Wan can be taken with Angelica sinensis and Radix et Rhizoma Ginseng. There is no contraindication to the use of Sishen Pills with Angelica sinensis and Radix et Rhizoma Ginseng, and Sishen Pills with Radix Angelica sinensis and Radix et Rhizoma Ginseng can be used in the treatment of spleen and kidney deficiency accompanied by symptoms of blood deficiency. Four Gods Pill is composed of nutmeg, bone marrow, schizandra, Wu Wei Zi, Cornu Cervi and so on, which has the effect of warming kidneys, warming spleen, fixing intestines and stopping diarrhea, and it can be used for spleen and kidney deficiency and cold, impecunious stool, dietary incontinence or eating but not transforming, or abdominal pain, fatigue (lack of spirit, physical fatigue), pale tongue with thin white coating, and slow and feeble pulse, etc. The drug can also be used to treat the symptoms of blood deficiency. Angelica Sinensis is sweet, pungent and warm in nature, belonging to the liver, heart and spleen meridians, with the effects of tonifying and invigorating blood, regulating menstruation, relieving pain, moistening the intestines and relaxing the bowels; Radix Angelicae Sinensis is sweet in flavor and flat in nature, belonging to the spleen and lung meridians, with the effects of strengthening the spleen and benefiting the lungs, nourishing the blood and generating fluid. The medicinal properties of Angelica sinensis, Radix et Rhizoma Ginseng and Sishen Pills are not mutually exclusive, so they can be taken together. The adverse reactions of Sishen Pills, Angelica sinensis and Radix et Rhizoma Ginseng are not clear, but it should be noted that they are prohibited for those who are allergic to Sishen Pills, and Radix et Rhizoma Ginseng is prohibited for those who suffer from fever and bleeding. It is recommended that the medication be administered under the guidance of a professional doctor.