The difference between Adapalene and Vitamin A cream is mainly reflected in the efficacy of the main treatment and mechanism of action, etc., which need to be specifically analyzed. 1. Efficacy: Adapalene is mainly used for the treatment of acne vulgaris, chest and back acne, including papules, pimples, pustular lesions and other diseases, while Vitamin A cream can be used for the treatment of blackheads, acne vulgaris and other chronic inflammatory diseases of the skin, but also for the treatment of hyperpigmented dermatosis, senile dermatitis, solar dermatitis, psoriasis and so on. 2. Mechanism of action: retinoic acid cream can affect melanogenesis, induce epidermal hyperplasia, regulate the abnormal keratinization of sebaceous glands, accelerate the synthesis of elastic fibers, and treat a variety of skin problems. Adapalene mainly reduces the formation of microcomedones by regulating the differentiation of hair follicle epithelial cells. It also corrects the abnormal keratinization and differentiation of the epidermis, thus inhibiting the development of unusual acne. It is Adapalene that may cause adverse reactions such as itching and flaking when used, and is contraindicated for people who are allergic to vitamin A derivatives. Vitamin A cream can also cause adverse reactions with symptoms of skin irritation when used, and is contraindicated in people who are allergic to it. Adapalene and Vitamin A cream should be used under the guidance of a doctor, patients need to go to the hospital when the skin disease occurs, do not blindly use their own medication, in order to avoid adverse consequences.