Thyroid 4c nodules are graded under thyroid ultrasound.Thyroid 4c nodules have a high risk of malignancy and can be examined by ultrasound-guided fine-needle aspiration pathology.If malignant, they can be surgically removed, and if benign, they can be reviewed periodically. Thyroid ultrasound TIRADS classification is used to guide the diagnosis of thyroid nodules and can grade the risk of malignancy of thyroid nodules (categories 0 to 6).Category 4c nodules are highly suspicious for malignancy with a malignancy risk of 50% to 90%. Thyroid nodules in category 4c have a high risk of malignancy, and ultrasound-guided fine-needle aspiration pathology can be performed to clarify the nature of the nodule. If malignant, prompt surgery is required, which usually includes total thyroidectomy, thyroid lobectomy, lumpectomy, microwave ablation, etc. If the nodule is benign, it can be observed for the time being and reviewed regularly. Thyroid 4c nodule patients should go to the hospital, complete the relevant examination under the guidance of the doctor standardized treatment.