Thrombocytopenia can be induced by cardiovascular drugs such as clopidogrel, ticlopidine, GpIIb/IIIa receptor inhibitors, and heparin. Clopidogrel-induced thrombocytopenia TTP occurs mostly within 2 weeks after administration, the incidence is very low and difficult to count, ticlopidine occurs mostly 2-12 weeks after administration, the incidence is about 1/5000 cases, the best treatment is not determined but plasma exchange is recommended.GpIIb/IIIa receptor inhibitor-induced thrombocytopenia occurs mostly in the early days after transfusion, with a significant drop in platelets, sometimes below 20×109 , and a high incidence of bleeding. Sometimes below 20 x 109 , bleeding occurs at a high rate and often requires transfusion therapy. Heparin-induced thrombocytopenia HIT occurs most often 5-14 days after the drug is administered, with positive monitoring of platelet factor 4 antibodies, moderate platelet decline, significant thrombocytopenia is relatively rare, and bleeding is rarely experienced, but thrombotic complications are more frequent. Heparin can no longer be used, but drugs such as the direct thrombin inhibitors bivalirudin and argatroban can be used. If the underlying thrombocytopenia, coronary heart disease requires stent placement must consider the risk of bleeding caused by antiplatelet drugs, if the risk of bleeding is large, can not apply antiplatelet drugs aspirin and clopidogrel, not recommended to do stenting, if the risk of bleeding is small, you can choose stenting, but it is recommended to apply the bare stent, aspirin and clopidogrel combination of a short period of time, as far as possible, to choose the radial artery route. Reduce puncture complications and also monitor for other bleeding complications. If thrombocytopenia is caused by immune factors, immunoglobulin can also be applied preoperatively. In this case, the patient was more than 20 days post-infarction, and it was estimated that drugs such as clopidogrel, heparin, or GpIIb/IIIa receptor inhibitors had been applied after admission, so care should be taken to identify thrombocytopenia induced by the above cardiovascular drugs.